FIELD: medicine.
SUBSTANCE: invention relates to a non-aqueous composition for enhancing transcutaneous suction of tizanidine or tizanidine hydrochloride, a matrix-type patch comprising such a non-aqueous composition dispersed in an adhesive layer, as well as to an agent for transcutaneous suction of tizanidine or tizanidine hydrochloride. Non-aqueous composition for enhancing transcutaneous suction of tizanidine or tizanidine hydrochloride contains tizanidine or tizanidine hydrochloride and sorbic acid and/or its salt with a metal. Concentration of sorbic acid and/or its salt with metal is 0.5–2.5 mol per mol of tizanidine or tizanidine hydrochloride.
EFFECT: providing a non-aqueous composition for enhancing transcutaneous suction having an increased permeability of the basic drug.
5 cl, 5 tbl, 6 ex
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