FIELD: biotechnology; immunology; medicine.
SUBSTANCE: invention relates to the field of biotechnology, immunology, medicine. An expression vector based on human adenovirus 5 serotype with deletion of E1 and E3 regions, carrying a modified hemagglutinin gene of influenza A virus of antigenically distant subtype H1, capable of inducing cross-protective immunity against infection caused by influenza A viruses of subtype H1 pathogenic to humans, without the effect of antigenic imprinting when administered to a subject as part of a pharmaceutical composition or influenza vaccine. A pharmaceutical composition based on it is also presented. The invention can be used in the pharmaceutical industry for the production of influenza vaccines.
EFFECT: invention makes it possible to create a viral vector expressing the gene of the target antigen that induces immunity to various strains of the human influenza A virus subtype H1 without the effect of antigenic imprinting, which can be used as a pharmaceutical composition for the prevention of influenza A subtype H1, and also be part of an influenza vaccine.
3 cl, 7 dwg, 2 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| EXPRESSION VECTOR BASED ON HUMAN ADENOVIRUS SEROTYPE 5 INDUCING CROSS-PROTECTIVE IMMUNITY TO INFLUENZA A SUBTYPE H3 VIRUSES AND PHARMACEUTICAL COMPOSITION BASED ON IT | 2023 |
|
RU2814189C1 |
| VACCINE AGAINST INFLUENZA TYPE A, INFLUENZA TYPE B AND COVID-19 | 2021 |
|
RU2751485C1 |
| STRAIN OF A RECOMBINANT PSEUDO ADENOVIRAL PARTICLE BASED ON HUMAN ADENOVIRUS GENOME OF SEROTYPE 5 Ad5-tetOFF-E3-HA125 SEROTYPE, CARRYING HAEMAGGLUTININ CONSENSUS GENE OF INFLUENZA VIRUS SUBTYPES H1, H2, H5 FOR PRODUCING INFLUENZA IMMUNOGENIC PREPARATIONS, METHOD FOR PRODUCING GENE | 2018 |
|
RU2713722C1 |
| RECOMBINANT TRIVALENT INFLUENZA VACCINE | 2012 |
|
RU2485973C1 |
| UNIVERSAL ANTI-INFECTIOUS VACCINE | 2015 |
|
RU2618918C2 |
| RECOMBINANT PSEUDO ADENOVIRAL PARTICLE BASED ON HUMAN BEING ADENOVIRUS GENOME OF 5-TH SEROTYPE FOR INDUCTION OF SPECIFIC IMMUNITY TO INFLUENZA VIRUS A OF H1N1 SUBTYPE AND METHOD OF ITS USE AS COMPONENT FOR VACCINE PRODUCTION | 2012 |
|
RU2507257C1 |
| RECOMBINANT PSEUDO-ADENOVIRUS PARTICLE BASED ON GENOME OF HUMAN ADENOVIRUS OF SEROTYPE 5, PRODUCING INFLUENZA HEMAGGLUTININ OF STRAIN A/Brisbane/59/2007(H1N1) AND METHOD OF ITS USE | 2012 |
|
RU2523599C1 |
| BROAD-SPECTRUM M2 PROTEIN ECTODOMAIN AVIAN INFLUENZA TYPE A VACCINE | 2014 |
|
RU2571944C1 |
| RECOMBINANT PSEUDO ADENOVIRAL PARTICLE BASED ON HUMAN BEING ADENOVIRUS GENOME OF 5-TH SEROTYPE FOR INDUCTION OF SPECIFIC IMMUNITY TO INFLUENZA VIRUS A OF H3N2 SUBTYPE AND METHOD OF ITS USE | 2012 |
|
RU2507258C1 |
| ANTIVIRAL SIMILAR MINI-ANTIBODY, NUCLEOTIDE SEQUENCE, EXPRESSING RECOMBINANT VIRAL VECTOR, PHARMACEUTICAL COMPOSITION AND METHOD FOR PREVENTION OR THERAPY OF INFLUENZA TYPE A | 2013 |
|
RU2536956C1 |
