COMPOUNDS FOR TREATING COMPLEMENT-MEDIATED DISORDERS Russian patent published in 2019 - IPC C07D401/14 C07D403/12 C07D403/14 C07D471/04 C07D513/04 C07D495/04 A61K31/404 A61K31/4162 A61K31/4155 A61K31/541 A61P9/00 A61P27/02 A61P19/02 A61P13/12 A61P11/00 A61P7/06 

FIELD: chemistry.

SUBSTANCE: invention refers to compounds of formula I possessing the properties of a compliment factor D factor inhibitor, a pharmaceutical composition based thereon and use thereof. In general formula IQ¹ is C(R¹R^1'); Q² is C(R²R^2'); Q³ is C(R³R³); (a) X¹ and X² independently represent N or CH, or (b) X¹ and X² together form C = C; A represents a group selected from

.

L is a bond oror B is 3–7-member monocyclic or bicyclic carbocyclic group or 4–6-member monocyclic or bicyclic heterocyclic group, having 1 or 2 N atoms, or B is -(C₀-C₄alkyl)(phenyl), -(C₀-C₄alkyl)(5 or 6-member heteroaryl with 1 or 2 heteroatoms independently selected from N, O and S), or - (C₀-C₄alkyl) (biphenyl); each of B is unsubstituted or substituted with one or more substitutes independently selected from (w) and (x), and 0 or 1 substitute selected from (z). Values of other substitutes are specified in the claim.

EFFECT: treating disorders mediated by factor D complement system, such as retinal degeneration, ophthalmic disease, multiple sclerosis, arthritis, COPD, respiratory disease, cardiovascular disease, and so forth.

49 cl, 1 tbl, 9 ex