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(19)

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2 830 173

(13)

(51)

IPC

C07D401/14(2006-01-01)

C07D471/04(2006-01-01)

C07D519/00(2006-01-01)

C07K5/83(2006-01-01)

A61K31/437(2006-01-01)

A61K31/4545(2006-01-01)

A61K31/496(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2021108405, 2019-09-07

(24)

Start date

2019-09-07

(22)

Actual filing date

2019-09-07

(45)

Published

2024-11-14

(72)

Inventor

Crew, Andrew P.Hornberger, Keith R.Wang, JingCrews, Craig M.Jaime-Figueroa, SaulDong, HanqingQian, YiminZimmerman, Kurt

(73)

Holder

Arvinas Operations, Inc.Yale University

POLYCYCLIC COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF POLYPEPTIDES OF FAST ACCELERATED FIBROSARCOMA Russian patent published in 2024 - IPC C07D401/14 C07D471/04 C07D519/00 C07K5/83 A61K31/437 A61K31/4545 A61K31/496 A61P35/00

Abstract RU 2830173 C2

FIELD: medicine; chemistry.

SUBSTANCE: invention relates to bifunctional compounds containing a fragment which binds the target protein and a fragment which binds E3-ubiquitin ligase. Bifunctional compounds are used as modulators of targeted ubiquitination with respect to fast-accelerated fibrosarcoma B-Raf proteins, which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention.

EFFECT: compounds are intended for preparing a drug having BRaf inhibiting activity.

3 cl, 10 dwg

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RU 2 830 173 C2

Authors

Crew, Andrew P.

Hornberger, Keith R.

Wang, Jing

Crews, Craig M.

Jaime-Figueroa, Saul

Dong, Hanqing

Qian, Yimin

Zimmerman, Kurt

Dates

2024-11-14—Published

2019-09-07—Filed