PROLONGED RELEASE PHARMACEUTICAL COMPOSITION Russian patent published in 2019 - IPC A61K31/444 A61K47/10 A61K47/14 A61K47/20 A61K47/34 A61P27/02 

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, namely to ophthalmology, and is intended for continuous release of ophthalmic drug. Ophthalmic depot preparation contains a drug, benzyl benzoate and/or benzyl alcohol and polyethylene glycol and/or dimethylsulphoxide. Volumetric ratio of benzyl benzoate and/or benzyl alcohol to polyethylene glycol and/or dimethyl sulphoxide ranges from 75:25 to 25:75. Total amount of contained benzyl benzoate and/or benzyl alcohol and polyethylene glycol and/or dimethyl sulphoxide is 50 % (wt./wt.) or more. Said depot formulation does not contain a copolymer of lactic and glycolic acids. Another embodiment is a container made from glass, cycloolefin polymer, polyolefin or polycarbonate and filled with said depot preparation. Also disclosed is a method of stabilizing 2-[[[2-[(hydroxyacetyl)amino]-4-pyridinyl]methyl]thio]-N-[4-(trifluoromethoxy)phenyl]-3-pyridine carboxamide or its salt contained in said ophthalmic depot preparation by administering tocopherol or derivatives thereof into said depot preparation.

EFFECT: use of the group of inventions provides a gradual continuous release of the drug after administration thereof, wherein said ophthalmic preparation is able to equally form a depot irrespective of the site of introduction or conditions around said portion and stably achieve prolonged release of the drug.

19 cl, 1 dwg, 15 tbl, 36 ex