DEPOT DRUG CONTAINING CITRIC ACID ESTER Russian patent published in 2021 - IPC A61K47/14 A61K47/34 A61K31/444 A61K31/4427 A61K9/08 A61K9/10 A61P27/02 A61P27/06 A61P31/04 

FIELD: medicine.

SUBSTANCE: group of inventions relates to a depot composition for the prevention and/or treatment of an eye disease containing an effective amount of the drug and trialkyl citrate and/or acetyltrialkyl citrate, in which the alkyl groups possessed by each of the trialkyl citrate and acetyltrialkyl citrate are the same and have a number of carbon atoms of 4, also refers to a depot formation method involving the injection of a liquid composition, containing an effective amount of the drug and trialkyl citrate and/or acetyltrialkyl citrate, in the eye, where the alkyl groups possessed by each of the trialkyl citrate and acetyltrialkyl citrate are the same and have a carbon atom number of 4; and the depot is used to prevent and/or treat eye disease, also relates to the use of trialkyl citrate and/or acetyltrialkyl citrate, wherein the alkyl groups possessed by each of the trialkyl citrate and acetyltrialkyl citrate are the same and have the number of carbon atoms 4, to produce a depot composition and to form a depot in the eye.

EFFECT: group of inventions provides a composition that has a high level of safety and can form a depot that provides improved properties of prolonged release of the drug compared to conventional compositions containing acetyltriethyl citrate.

18 cl, 15 tbl, 4 dwg