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(19)

(11)

2 704 992

(13)

(51)

IPC

C07K14/00(2006-01-01)

A61K38/05(2006-01-01)

A61K38/17(2006-01-01)

C07K14/78(2006-01-01)

C12N15/11(2006-01-01)

C12N15/63(2006-01-01)

(21) (22)

Application

2014117511, 2012-10-10

(24)

Start date

2012-10-10

(22)

Actual filing date

2012-10-10

(45)

Published

2019-11-01

(72)

Inventor

Kojl EntoniBaka ManuelTisted TomasDrabik StejsiGrinberg LyubaNovarra ShabazzOganesyan VakhekhKherbst RonaldSpenser Devid Kennet

(73)

Holder

Medimmyun, Elelsi

CD40L-SPECIFIC CARCASS STRUCTURES DERIVED FROM Tn3, AND METHODS FOR USE THEREOF Russian patent published in 2019 - IPC C07K14/00 A61K38/05 A61K38/17 C07K14/78 C12N15/11 C12N15/63

Abstract RU 2704992 C2

FIELD: biotechnology.

SUBSTANCE: present invention relates to biotechnology, specifically to framework structures based on FnIII-domain tenascin-3 (Tn3). Invention enables to obtain a framework structure capable of specifically binding CD40L and having high affinity for the target compared to known analogues.

EFFECT: constructed frame structures of the present invention can be used as preventive, diagnostic or therapeutic agents, particularly for therapeutic applications against SLE and other autoimmune diseases and conditions.

41 cl, 19 dwg, 10 tbl, 7 ex

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RU 2 704 992 C2

Authors

Kojl Entoni

Baka Manuel

Tisted Tomas

Drabik Stejsi

Grinberg Lyuba

Novarra Shabazz

Oganesyan Vakhekh

Kherbst Ronald

Spenser Devid Kennet

Dates

2019-11-01—Published

2012-10-10—Filed