FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology, specifically to framework structures based on FnIII-domain tenascin-3 (Tn3). Invention enables to obtain a framework structure capable of specifically binding CD40L and having high affinity for the target compared to known analogues.
EFFECT: constructed frame structures of the present invention can be used as preventive, diagnostic or therapeutic agents, particularly for therapeutic applications against SLE and other autoimmune diseases and conditions.
41 cl, 19 dwg, 10 tbl, 7 ex
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