IL-12 COMPOSITIONS AIMED AT EDB Russian patent published in 2021 - IPC C07K14/54 C07K16/18 C07K19/00 A61K38/20 A61K39/395 A61K47/68 A61P35/00 

Abstract RU 2758143 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, specifically to immunocytokines based on IL-12 fused with EDB-binding domains, and can be used in medicine for anti-tumour therapy where a malignant tumor expresses the extradomain B of fibronectin (EDB-FN).

EFFECT: proposed immunocytokine with SEQ ID NO: 16 provides an improved therapeutic potential of IL-12 by improving the biodistribution profile, tolerability, therapeutic window, and/or effectiveness in reaching the site of the disease.

8 cl, 11 dwg, 2 tbl, 3 ex

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RU 2 758 143 C1

Authors

Villa, Alessandra

Matasci, Mattia

Ongaro, Tiziano

Dates

2021-10-26Published

2019-02-08Filed