FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically to immunocytokines based on IL-12 fused with EDB-binding domains, and can be used in medicine for anti-tumour therapy where a malignant tumor expresses the extradomain B of fibronectin (EDB-FN).
EFFECT: proposed immunocytokine with SEQ ID NO: 16 provides an improved therapeutic potential of IL-12 by improving the biodistribution profile, tolerability, therapeutic window, and/or effectiveness in reaching the site of the disease.
8 cl, 11 dwg, 2 tbl, 3 ex
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