FIELD: biotechnology.
SUBSTANCE: invention refers to biotechnology, molecular biology and virology. Disclosed is a non-replicable, cell-absorbed rhabdovirus, which is a virus of vesicular stomatitis, wherein said virus is obtained by exposing the live virus to UV radiation used in dose of 100 mJ/cm2 up to 1000 mJ/cm2, so that at least 0.05 % but not more than 80 % of the nucleotides of the virus RNA are cross-linked and/or the virus RNA is split into at least two discrete polynucleotide sequences, and wherein the surface of the envelope of the viral particle contains at least 5 % of the number of G proteins of the wild-type virus particle.
EFFECT: invention can be used in medicine for leukemia treatment.
8 cl, 29 dwg, 2 tbl, 8 ex
| Title |
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