NOVEL PYRAZOLO[3,4-D]PYRIMIDINE COMPOUND OR SALT THEREOF Russian patent published in 2019 - IPC C07D487/04 A61K31/519 A61P35/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a novel compound of formula (I) or a pharmaceutically acceptable salt thereof, having inhibitor properties and having cytostatic effect. Compounds can be used for treating a tumor disease associated with HER2 activity. In formula (I)

(I)

X is 5-6-member nitrogen-containing saturated heterocyclic group, optionally containing a halogen atom or a C1-C6 alkyl group as a substitute; Y is -C(R₄)=C(R₅)(R₆); Z₁, Z₂, Z₃ and Z₄ are identical or different from each other and each represents a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group optionally substituted with halogen atoms, a C1-C6 alkyl group, an amino group optionally substituted with C1-C6 alkyl groups, a C3-C7 cycloalkyl group or 5-member unsaturated heterocyclic group containing 1 to 2 oxygen atoms as heteroatoms, or Z₁ and Z₂ or Z₃ and Z₄ optionally form together with corresponding carbon atoms bonded thereto, a benzene ring or 6-member unsaturated nitrogen-containing heterocyclic ring or 5-member saturated oxygen-containing heterocyclic ring; W is -CH₂-, an oxygen atom or -NH-; n is integer 0; R₁ is an unsubstituted amino group; R₂ and R₃ are identical or different from each other and each represents a C1-C6 alkoxy group, an unsubstituted C1-C6 alkyl group or a phenyl group or R₂ and R₃ optionally form together with nitrogen atom associated with them, 4-6-member nitrogen-containing saturated heterocyclic group optionally containing a hydroxyl group as a substitute; and R₄, R₅ and R₆ are identical or different from each other and each represents a hydrogen atom or a C1-C6 alkyl group, optionally substituted with a di-C1-C6-alkylamino group.

EFFECT: disclosed are novel pyrazolo[3,4-d]pyrimidine compound or a salt thereof.

16 cl, 13 tbl, 80 ex