METHOD FOR PREDICTION OF PRECANCER DISEASES OF STOMACH Russian patent published in 2019 - IPC G01N33/48 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely prediction of premalignant diseases of stomach, including assessment of presence in gastric mucosa of bacterium Helicobacter pylori. That is ensured by evaluating the quantitative level of Helicobacter pylori and Candida fungi, the degree of manifestation of duodenogastric reflux, the prevalence and structure of the follicles, and the duration of using the proton pump inhibitors. Derived clinical-laboratory data are used to calculate a prediction index of premalignant diseases by summation of points by each feature: degree of dissemination of H. Pylori bacteria: absence of H. Pylori – 0 points; + – 1 point; ++ – 2 points; +++ – 3 points; presence of mucosa contamination with Candida fungus: absence of yeast-like mycelium – 0 points; + – 1 point; ++ – 2 points; +++ – 3 points; manifestation of duodenogastric reflux: absence of duodenogastric reflux – 0 points; 1 degree – 1 point; 2 degree – 2 points; 3 degree – 3 points; presence and distribution of follicles: absence of follicles – 0 points; area of distribution 1/3 of antral part of stomach and height of follicles 0.1–0.2 cm – 1 point; area of localization of whole antral portion of stomach and height of follicles 0.2–0.3 cm – 2 points; area of localization of antrum and part of body of stomach and height of follicles of more than 0.4 cm – 3 points; duration of application of proton pump inhibitors: absence of such therapy – 0 points; up to 20 days – 1 point; from 21 days to 3 months – 2 points; from 3 months and more – 3 points, wherein the value of the prediction index of not more than 5 points indicates a low degree of probability of developing precancerous diseases, 6 to 8 points – on the average degree of probability of developing precancerous diseases, correcting the scheme of the therapy, from 9 to 15 points – a high degree of probability of developing precancerous diseases of stomach, which determines strict control of patient, timely correction of conducted therapy, repeated in dynamics endoscopic examination with taking biopsy material from area of follicles formation.

EFFECT: invention provides higher accuracy of prediction of precancer diseases of stomach by complex assessment of a number of characteristics of microflora and condition of mucous membrane of organ, its functional state, as well as conducted therapy, which allows for individual prediction.

1 cl, 1 tbl