FIELD: biochemistry.
SUBSTANCE: invention relates to biochemistry, particularly to use of a composition comprising a monoclonal antibody or a fragment thereof against MASP-3, which specifically binds to a portion of MASP-3 and inhibits factor D maturation, for preparing a drug for treating a subject.
EFFECT: invention enables effective treatment of a disease or disorder selected from a group consisting of age-related macular degeneration, arthritis, thrombotic microangiopathy, asthma, dense deposit disease, weakly immunized necrotising glomerulonephritis with half-moons, traumatic cerebral injury, aspiration pneumonia, neuromyelitis optica or Behcet's disease.
26 cl, 70 dwg, 22 tbl, 35 ex
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| ANALOGUES OF COMPLEMENT FACTOR B AND THEIR APPLICATION | 2012 |
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