FIELD: biotechnology.
SUBSTANCE: presented is using an inhibiting MASP-2 antibody or an antigen-binding fragment thereof, which inhibits MASP-2-dependent complement activation, for preparing a drug for treating a subject suffering from catastrophic antiphospholipid syndrome.
EFFECT: invention provides inhibition of cell damage associated with MASP-2 mediated activation of the alternative complement pathway, keeping the immune system component representing the classical (C1q-dependent) pathway intact.
18 cl, 78 dwg, 42 tbl, 43 ex
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