FIELD: biochemistry.
SUBSTANCE: invention relates to biochemistry, particularly to an isolated antibody or antigen-binding fragment thereof, which can specifically bind to human OX40, as well as a method for preparing it and a composition containing same. Also disclosed is a polynucleotide for expressing said antibody or its antigen-binding fragment, as well as a cell, a vector containing it. Invention also relates to a method of treating a malignant neoplasm in an individual, comprising administering to an individual an effective amount of an antibody or an antigen-binding fragment thereof, which can specifically bind to human OX40.
EFFECT: invention enables effective treatment of a malignant growth.
19 cl, 46 dwg, 12 tbl, 12 ex
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