GLA DOMAINS AS TARGETING AGENTS Russian patent published in 2020 - IPC A61K38/16 C07K14/705 A61P35/00 A61P31/12 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, specifically to recombinant polypeptides for targeting evolved phosphatidylserine. Described is a polypeptide for targeting the released phosphatidylserine, which involves: (a) protein S gamma-carboxyglutamic acid domain containing a sequence presented in SEQ ID NO: 1, or sequence of 95 % homologous thereto, and not containing a protease domain or a hormone-binding domain; and (b) a protein S of the EGF domain, wherein said polypeptide is conjugated with a payload selected from a detectable label, a protein sequence, polyethylene glycol, cellulose, albumin protein and a therapeutic agent. Pharmaceutical compositions for treating cancer and viral diseases. Invention can be used in medicine.

EFFECT: invention enables diagnosing and treating the disorders associated with the increase in the expression level of PtdS, which is associated with apoptosis.

33 cl, 8 dwg, 1 ex