FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology and immunology. Disclosed is a nucleotide composition for obtaining Fc heterodimeric construct having substitutions in the CH3 domains, providing an increase in the melting point. Host cell and method for expressing Fc heterodimeric construct is also provided.
EFFECT: present invention may be used in the development of therapeutic antibodies.
27 cl, 46 dwg, 16 tbl, 15 ex
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