FIELD: medicine.
SUBSTANCE: group of inventions refers to medicine, namely to a liquid pharmaceutical composition containing Glu-plasminogen or biologically active mutant Glu-plasminogen polypeptide, having at least 80 % amino acid sequence identity with native Glu-plasminogen polypeptide in concentration of 0.01 mg/ml to 80 mg/ml; a tonicity modifier which is sodium chloride in concentration of 30 mM to 100 mM, which enables to achieve osmolality of composition from 180 mOsm to 350 mOsm; and a stabilizer which is arginine or glycine, in concentration of 10 mM to 100 mM; and wherein the pH of the composition ranges from 5.0 to 8.0, also relates to use of the pharmaceutical composition.
EFFECT: group of inventions provides producing a pharmaceutical composition of Glu-plasminogen with improved stability.
21 cl, 22 dwg, 17 tbl, 13 ex
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