CREATING CONTROLLED RELEASE PROFILE OF DRUG SUBSTANCE USING LIPOSOMAL COMPOSITION IN AQUEOUS AND ANHYDROUS SOLUTIONS Russian patent published in 2020 - IPC A61K9/127 A61K31/4375 A61K31/475 A61K31/721 A61K36/24 A61K47/28 A61K47/24 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: group of inventions refers to pharmaceutical industry, in particular to embodiments of a pharmaceutical composition for inhibiting growth of cancer cells. In one embodiment, the composition includes a component which forms a particle selected from a phospholipid and a mixture of at least one phospholipid and cholesterol; 0.1–10 mM dextran sulphate ion or its pharmaceutically acceptable salt; 100–500 mM ammonium sulphate; amphipathic therapeutic agent or its pharmaceutically acceptable salt. In another embodiment of the composition, the amount of ammonium sulphate is 150–450 mM, and the amphipathic therapeutic agent is a vinca roseacola alkaloid. Also disclosed are: a liposome for delivering an amphipathic therapeutic agent and a method of inhibiting growth of cancer cells by administering an effective amount of said pharmaceutical composition.

EFFECT: group of inventions provides optimal therapeutic effectiveness and reduced toxic effect on skin.

16 cl, 4 dwg, 11 tbl, 10 ex