PHARMACEUTICAL COMPOSITION FOR CONTROLLED RELEASE OF WEAK ACID DRUGS AND ITS USE Russian patent published in 2023 - IPC A61K31/573 A61K31/557 A61K31/5578 A61K47/12 A61K47/28 A61K47/24 A61K9/127 A61P11/00 

FIELD: medicine.

SUBSTANCE: group of inventions discloses a pharmaceutical composition for the treatment of pulmonary hypertension or interstitial lung disease, containing the following: one or more liposomes suspended in the external environment, wherein the said liposome contains: (a) an external lipid bilayer containing a mixture of a first phospholipid, a second phospholipid and sterol, and (b) an internal aqueous medium containing a weakly acidic drug that is a prostaglandin, a prostacyclin (IP) receptor agonist, an endothelin (ET) receptor antagonist, a glucocorticoid or a nonsteroidal anti-inflammatory drug (NSAID), or any combination thereof, and salt weak acid, which is a carboxylic acid salt or bicarbonate salt, where the ratio of first phospholipid: sterol: second phospholipid in mole percent is 75-99:0-14.9:0.1-25. The group of inventions also discloses a method of treating pulmonary hypertension or interstitial lung disease and a method of reducing the side effects of a weakly acidic drug.

EFFECT: claimed group of inventions provides high therapeutic activity, with a reduction in potential side effects due to the liposomal composition that does not provide an initial explosive release.

24 cl, 2 dwg, 6 tbl, 6 ex