XIa FACTOR INHIBITORS Russian patent published in 2020 - IPC C07D221/04 C07D401/10 A61K31/4375 A61P7/02 A61P7/04 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a novel compound of formula I or a pharmaceutically acceptable salt thereof. In formula I

,

where X denotes -(C=O)NH- or -NH(C=O)-; R¹ denotes phenyl, where said phenyl group is optionally substituted with one to three substitutes independently selected from a group consisting of halogen, R⁴, (C=O)OR⁴, NH(C=O)OR⁴ and 5-member heteroaryl containing 4 nitrogen atoms; R² denotes hydrogen, hydroxy, halogen or C_1-6 alkyl, where said alkyl is optionally substituted with one substitute selected from C_3-6 cycloalkyl; R³ denotes phenyl or C_3-10 cycloalkyl, where said phenyl and cycloalkyl group are optionally substituted with one substitute selected from (C=O)OR⁴; R⁴ is hydrogen or C_1-6 alkyl; R^x is hydrogen, hydroxy or halogen; R^z denotes hydrogen.

EFFECT: compound has the properties of a coagulation factor inhibitor hFXIa and can be used for treating venous thromboembolia and pulmonary embolism, as well as in producing a drug for inhibiting thrombin, inhibiting thrombosis, treating thrombosis or preventing thrombosis.

16 cl, 4 ex