FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology. Described is a group of inventions comprising a compound comprising a modified oligonucleotide for reducing mRNA and/or a PKK protein (embodiments), a conjugated antisense compound containing said compound for reducing mRNA expression and/or the PKK protein, a composition for preventing, treating or ameliorating the PKK related disease, disorder or condition, using the compound and using the composition for preventing, treating or relieving the PKK related disease, disorder or condition, using the compound and using the composition for treating an inflammatory disease or thromboembolic disease. In one embodiment, the compound consists of a modified oligonucleotide according to the following formula: Tes Ges mCes Aes Aes Gds Tds mCds Tds mCds Tds Tds Gds Gds mCds Aes Aes Aes mCes Ae, where A = adenine, mC = 5'-methylcytosine, G = guanine, T = thymine, e = 2'-O-methoxyethyl-modified nucleoside, d = 2'-deoxynucleoside and s = internucleoside phosphorothioate linkage.
EFFECT: invention extends the range of agents for reducing mRNA and/or PKK protein.
43 cl, 2 dwg, 85 tbl, 22 ex
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