FIELD: biotechnology.
SUBSTANCE: described is a group of inventions comprising a modified oligonucleotide which is capable of reducing the amount of mRNA and/or protein C90RF72, composition containing an effective amount of said modified oligonucleotide, use of the modified oligonucleotide for treating a disease, disorder or condition associated with C90RF72, and use of the composition for treating a disease, disorder or condition associated with C90RF72. In one embodiment, the modified oligonucleotide consists of 12–30 linked nucleosides and has a nucleic acid sequence, containing at least 12 consecutive nucleobases of any of the sequences of nucleobases of SEQ ID NO: 20–401, 441–1545.
EFFECT: invention extends the range of agents for reducing the amount of mRNA and/or protein C90RF72.
39 cl, 95 tbl, 16 ex
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