ORALLY DISINTEGRATING SOLID PHARMACEUTICAL DOSAGE UNIT CONTAINING A GENERIC ACTIVITY CONTROLLING SUBSTANCE Russian patent published in 2020 - IPC A61K9/16 A61K9/20 A61K38/95 A61K47/36 A61P15/06 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: present invention provides an orally disintegrating solid pharmaceutical dosage unit having a weight ranging from 50 to 1000 mg, wherein said dosage unit consists of: 5–100 wt % having a coating particles, containing 50–99 wt % core particle and 1–50 wt % coating, which covers from all sides core particle, wherein said coating consists of: 0.01–10 wt % generic activity controlling substance selected from oxytocin, carbetocin, atosiban and combinations thereof; 5–50 wt % a buffer agent; 15–80 wt % a branched glucan selected from dextran, glycogen, amylopectin and a combination thereof; 0.02–78 wt % other pharmaceutically acceptable ingredients; 1–95 wt % one or more pharmaceutically acceptable excipients; wherein said solid dosage unit includes at least 20 mcg of generic activity controlling substance and has a pH value of buffer within 3.5–5.7.

EFFECT: disclosed is an orally disintegrating solid pharmaceutical dosage unit containing a generic activity controlling substance.

14 cl, 12 tbl, 6 ex