FIELD: medicine.
SUBSTANCE: group of inventions relates to a method of treating or slowing the progression of non-squamous non-small cell lung cancer (NSCLC) in an individual, comprising administering to an individual an effective amount of an antagonist binding to a component of the PD-1 signaling pathway, taxane and a platinum-based chemotherapeutic agent, wherein the taxane is nab-paclitaxel or paclitaxel. Group of inventions also relates to a method of enhancing immune function in an individual with non-squamous NSCLC, comprising administering an antagonist which binds to a component of a PD-1 signaling pathway, taxane and a platinum-based chemotherapeutic agent; combinations for treating or slowing the progression of non-flat-cell NSCLC in an individual; kit for treating or delaying the progression of non-squamous NSCLC in an individual.
EFFECT: group of inventions provides a strong antitumour effect, including a high frequency of "complete remission", id est no detectable tumor mass.
95 cl, 2 ex, 6 dwg, 5 tbl
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RU2800779C2 |
METHODS FOR TREATING CANCER, INCLUDING TIGIT-BINDING AGENTS | 2017 |
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TARGETED TGF BETA INHIBITION | 2015 |
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Authors
Dates
2020-04-17—Published
2014-12-17—Filed