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2 748 943

(13)

(51)

IPC

C07K16/28(2006-01-01)

C12N15/13(2006-01-01)

C12N15/63(2006-01-01)

A61K39/395(2006-01-01)

A61P35/00(2006-01-01)

G01N33/574(2006-01-01)

(21) (22)

Application

2018100820, 2016-06-16

(24)

Start date

2016-06-16

(22)

Actual filing date

2016-06-16

(45)

Published

2021-06-02

(72)

Inventor

Hotzel, IsidroJunttila, Teemu, T.Li, JiScheer, JustinDicara, DanielleEllerman, DiegoSpiess, ChristophCarter, Paul

(73)

Holder

Genentech, Inc.

HUMANIZED ANTIBODIES AND ANTIBODIES WITH MATURE AFFINITY AGAINST FcRH5 AND METHODS FOR THEIR APPLICATION Russian patent published in 2021 - IPC C07K16/28 C12N15/13 C12N15/63 A61K39/395 A61P35/00 G01N33/574

Abstract RU 2748943 C2

FIELD: biochemistry.

SUBSTANCE: invention relates to the field of biochemistry, in particular to an antibody against Fc-receptor-like Protein 5 (FcRH5). The nucleic acid encoding the specified antibody, the vector and host cell expressing the specified antibody, the immunoconjugate, the composition and the set containing the specified antibody are also disclosed. Methods for obtaining the said antibody, treating, FcRH5 detecting and enhancing immune function with the help of the said antibody, using the said antibody to manufacture a drug to treat or slow the progression of FcRH5-positive cancer in a subject, using the said antibody to manufacture a drug to enhance immune function in a subject having FcRH5-positive cancer are disclosed.

EFFECT: invention makes it possible to effectively treat cancer associated with FcRH5.

151 cl, 41 dwg, 15 tbl, 6 ex

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RU 2 748 943 C2

Authors

Hotzel, Isidro

Junttila, Teemu, T.

Li, Ji

Scheer, Justin

Dicara, Danielle

Ellerman, Diego

Spiess, Christoph

Carter, Paul

Dates

2021-06-02—Published

2016-06-16—Filed