FIELD: biotechnology.
SUBSTANCE: invention relates to bispecific antigen-binding molecules having a monovalent arm specific to a first target antigen such as CD3 and a bivalent arm specific to a second target antigen such as HER2, methods of their production and use. Also the following is provided: an isolated nucleic acid encoding a bispecific antigen-binding molecule, an expression vector, a host cell for obtaining a bispecific antigen-binding molecule, kits for encoding and obtaining a bispecific antigen-binding molecule, an immunoconjugate and a composition for treating or slowing the progression of HER2-positive cancer, a method of treating or slowing progression of HER2 positive cancer in a subject, a method of enhancing immune function in a subject having HER2 positive cancer, and a kit for treating or slowing the progression of HER2 positive cancer in a subject.
EFFECT: group of inventions is used for the treatment of pathological conditions such as HER2-positive cancer.
62 cl, 14 tbl, 42 dwg, 12 ex
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