FIELD: medicine; pharmaceuticals.
SUBSTANCE: present invention relates to a polymer conjugate of platinum (II) complex, as well as to a method for its preparation. Polymer conjugate contains a block copolymer containing a polyethylene glycol structural fragment and a polyaspartic or polyglutamic acid fragment, a sulphoxide derivative, built-in side chain carboxyl group in block copolymer, and platinum (II) complex, which forms coordination bonds with sulphoxide group of sulphoxide derivative. Platinum (II) complex is a cis-coordinated complex.
EFFECT: obtained polymer conjugate relates to a drug delivery system (DDS preparation) for a platinum complex and exhibits high anti-tumor activity as a drug and reduced side effects.
3 cl, 6 tbl, 11 ex
| Title | Year | Author | Number |
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| COORDINATION COMPLEX OF PLATINUM (II) DIAMINOCYCLOHEXANE WITH BLOCK COPOLYMER CONTAINING POLYCARBOXYLIC ACID SEGMENT AND INCLUDING ANTICANCER AGENT | 2004 |
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| DIPHOSPHINE AND METAL COMPLEXES | 2006 |
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| METHOD OF OBTAINING A BLOCK COPOLYMER | 2012 |
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| PEPTIDOMIMETIC COMPOUNDS AND THEIR CONJUGATES OF ANTIBODIES WITH DRUGS | 2014 |
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