METHOD OF OBTAINING A BLOCK COPOLYMER Russian patent published in 2017 - IPC C08G73/10 A61K9/48 A61K47/34 A61P35/00 C08G65/333 

FIELD: chemistry.

SUBSTANCE: block copolymer has the following formula (1):

,

where R1 is a hydrogen atom or a (C1-C5) alkyl group; R2 is a (C1-C5) alkylene group; R3 is a methylene or ethylene group; R4 represents a hydrogen atom or a (C1-C4) acyl group; R5 is a hydroxyl group, an aryl (C1-C8) alkoxy group which may have a substituent, or -N (R6) -CO-NHR7, where R6 and R7 may be the same or different and each represents a cyclic (C3-C6) An alkyl group or a (C1-C5) alkyl group which may be substituted with a tertiary amino group; N is 20-500; M is 2-200; But is 0-100; B is 0-100, provided that the sum of a and b is greater than or equal to 1 and not more than m; The fraction of the R5 group representing the hydroxyl group is 0-5% of m; proportion of the R5 group representing an aryl (C1-C8) alkoxy group which may have a substituent is 10-80% of m; The fraction of the R5 group representing -N (R6) -CO-NHR7 is 11-30% of m. The process for preparing the block copolymer is that the compound of the formula (2)

is reacted, wherein R1, R2, R3, R4, n are as defined above; x is 0-100, y is 0-100, the sum of x and y is 2-200, with aryl (C1-C8) alkyl alcohol, and a carbodiimide-based compound in an amount of 2(x+y) equivalents or more relative to the amount of carboxyl Groups in the compound of formula (2). The reaction is carried out in a solvent at a temperature of 15-30°C for 2-48 hours.

EFFECT: invention allows to maintain the process in a single reactor, reduce manufacturing period and reduce the quantity of solvent.

4 cl, 1 tbl, 6 ex