ETHYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR Russian patent published in 2020 - IPC C07D401/10 C07D239/70 C07D471/10 C07D487/10 C07D491/107 C07D491/20 A61K31/527 A61P25/28 A61P35/00 A61P1/08 A61P3/10 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a novel compound of formula I or a pharmaceutically acceptable acid addition salt or corresponding enantiomer thereof. In formula I

R¹ is lower alkyl; R² is phenyl or pyridinyl, wherein the N atom in the pyridinyl group can be in different positions; n equals 0, 1 or 2; V/U are independently O or CH₂, where V and U can not be simultaneously O; L is a five- or six-membered heteroaryl group selected from

.

EFFECT: compounds have glutamate 4 metabotropic receptor activity and can be used for treating Parkinson's disease, anxiety, vomiting, obsessive-compulsive disorder, autism, cancer, depression, type 2 diabetes and neuroprotection.

15 cl, 1 dwg, 4 tbl, 17 ex