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2 726 077

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IPC

G09B23/28(2006-01-01)

A61K31/351(2006-01-01)

A61K31/519(2006-01-01)

A61K35/28(2015-01-01)

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Application

2020111727, 2020-03-21

(24)

Start date

2020-03-21

(22)

Actual filing date

2020-03-21

(45)

Published

2020-07-08

(72)

Inventor

Fejziev Elvin Ejnulla OglyBelous Aleksandr SergeevichSukovatykh Boris SemenovichTrubnikova Elena Vladimirovna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Universitet"

METHOD FOR PHARMACOLOGICAL CORRECTION OF EXPERIMENTAL CRITICAL SKELETAL MUSCLE ISCHEMIA WITH A COMBINATION OF SIMVASTATIN, UDENAFIL AND MONONUCLEAR FRACTION OF AUTOLOGOUS BONE MARROW Russian patent published in 2020 - IPC G09B23/28 A61K31/351 A61K31/519 A61K35/28

Abstract RU 2726077 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to experimental pharmacology and surgery, and can be used to simulate critical skeletal muscle ischemia. Method for pharmacological correction of experimental critical skeletal muscle ischemia with a combination of simvastatin, udenafil and mononuclear fraction of autologous bone marrow involves experimental modeling of critical ischemia of shin muscles, where simvastatin is administered intragastrically in dose of 0.86 mg/kg, udenafil is administered intragastrically in dose of 0.86 mg/kg once a day daily for 7 days and a mononuclear fraction of autologous bone marrow is introduced once parenterally on 7th day after simulating critical ischemia 50 mcl into 4 points.

EFFECT: invention provides developing a method for pharmacological correction of critical shin muscles ischemia in experimental simvastatin animals.

1 cl, 1 ex, 1 tbl

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RU 2 726 077 C1

Authors

Fejziev Elvin Ejnulla Ogly

Belous Aleksandr Sergeevich

Sukovatykh Boris Semenovich

Trubnikova Elena Vladimirovna

Dates

2020-07-08—Published

2020-03-21—Filed