FIELD: medicine.
SUBSTANCE: calf muscle ischemia is simulated, including in a combination with additional simulation of nitrogen oxide deficiency by intraperitoneal introduction of the nitrogen oxide synthesis blocker N-nitro-L-arginine of methyl ester (L-NAME) 25 mg/kg daily for 7 days. In both cases, the ischemia is corrected by intragastric introduction of sildenafil 2.2 mg/kg on the first, third and fifth days of experiment.
EFFECT: significant improvement of microcirculation in the ischemic calf muscle of rats.
1 tbl, 1 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD OF PHARMACOLOGICAL CORRECTION OF EXTREMITY ISCHEMIA INCLUDING IN L-NAME INDUCED NITROGEN OXIDE DEFICIENCY | 2010 |
|
RU2426174C1 |
METHOD FOR SKELETAL MUSCLE EXPERIMENTAL ISCHEMIA PHARMACOLOGICAL CORRECTION USING SILDENAFIL AND PENTOXIFYLLINE IN COMBINED THERAPY | 2016 |
|
RU2618621C1 |
METHOD FOR PHARMACOLOGICAL CORRECTION OF EXPERIMENTAL CRITICAL SKELETAL MUSCLE ISCHEMIA WITH A COMBINATION OF SIMVASTATIN AND UDENAFIL | 2020 |
|
RU2727891C1 |
METHOD FOR SKELETAL MUSCLE EXPERIMENTAL ISCHEMIA PHARMACOLOGICAL CORRECTION USING VARDENAFIL AND PENTOXIFYLLINE IN COMBINED THERAPY | 2016 |
|
RU2618622C1 |
METHOD FOR SKELETAL MUSCLE EXPERIMENTAL ISCHEMIA PHARMACOLOGICAL CORRECTION USING TADALAFIL AND PENTOXIFYLLINE IN COMBINED THERAPY | 2016 |
|
RU2618620C1 |
METHOD FOR PHARMACOLOGICAL CORRECTION OF EXPERIMENTAL CRITICAL SKELETAL MUSCLE ISCHEMIA WITH A COMBINATION OF SIMVASTATIN, UDENAFIL AND MONONUCLEAR FRACTION OF AUTOLOGOUS BONE MARROW | 2020 |
|
RU2726077C1 |
METHOD OF TADALAFIL-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
|
RU2364395C1 |
METHOD FOR PHARMACOLOGICAL CORRECTION OF SCELETAL MUSCLE ISCHEMIA WITH MINOXIDIL | 2012 |
|
RU2497200C1 |
METHOD FOR PHARMACOLOGICAL CORRECTION OF SKELETAL MUSCLE ISCHEMIA WITH NICORANDYL | 2012 |
|
RU2507597C2 |
METHOD FOR STIMULATING NEOANGIOGENESIS IN ISCHEMIC SKELETAL MUSCLE | 2014 |
|
RU2547692C1 |
Authors
Dates
2013-10-27—Published
2012-02-13—Filed