METHOD OF PHARMACOLOGICAL CORRECTION OF SCELETAL MUSCLE ISCHEMIA WITH SILNEDAFIL INCLUDING IN L-NAME INDUCED NITROGEN OXIDE DEFICIENCY Russian patent published in 2013 - IPC G09B23/28 A61K31/522 A61P9/10 

Abstract RU 2497203 C2

FIELD: medicine.

SUBSTANCE: calf muscle ischemia is simulated, including in a combination with additional simulation of nitrogen oxide deficiency by intraperitoneal introduction of the nitrogen oxide synthesis blocker N-nitro-L-arginine of methyl ester (L-NAME) 25 mg/kg daily for 7 days. In both cases, the ischemia is corrected by intragastric introduction of sildenafil 2.2 mg/kg on the first, third and fifth days of experiment.

EFFECT: significant improvement of microcirculation in the ischemic calf muscle of rats.

1 tbl, 1 ex

Similar patents RU2497203C2

Title Year Author Number
METHOD OF PHARMACOLOGICAL CORRECTION OF EXTREMITY ISCHEMIA INCLUDING IN L-NAME INDUCED NITROGEN OXIDE DEFICIENCY 2010
  • Pokrovskij Mikhail Vladimirovich
  • Lazarenko Viktor Anatol'Evich
  • Kolesnik Inga Mikhajlovna
  • Pokrovskaja Tat'Jana Grigor'Evna
  • Danilenko Ljudmila Mikhajlovna
  • Korolev Anton Evgen'Evich
  • Korokin Mikhail Viktorovich
  • Ragulina Vera Alekseevna
  • Gudyrev Oleg Sergeevich
  • Bezhin Aleksandr Ivanovich
  • Lopatin Dmitrij Vladimirovich
  • Egorova Ekaterina Olegovna
  • Novikov Oleg Olegovich
  • Arustamova Anna Aleksandrovna
  • Narykov Roman Aleksandrovich
  • Denisjuk Tat'Jana Alekseevna
  • Titareva Ljudmila Viktorovna
  • Sytnik Mikhail Vladimirovich
  • Gureev Vladimir Vladimirovich
  • Losenok Polina Igorevna
  • Sarojan Karen Vanushevich
  • Korokina Lilija Viktorovna
  • Loktionova Inna Leonidovna
  • Mal'Tseva Natal'Ja Viktorovna
  • Orlova Anzhelika Jur'Evna
RU2426174C1
METHOD FOR SKELETAL MUSCLE EXPERIMENTAL ISCHEMIA PHARMACOLOGICAL CORRECTION USING SILDENAFIL AND PENTOXIFYLLINE IN COMBINED THERAPY 2016
  • Lavrinenko Kristina Ivanovna
  • Belous Aleksandr Sergeevich
  • Mal Galina Sergeevna
  • Artyushkova Elena Borisovna
  • Polyakova Olga Vitalevna
  • Orlova Anzhelika Yurevna
  • Trubnikova Elena Vladimirovna
RU2618621C1
METHOD FOR PHARMACOLOGICAL CORRECTION OF EXPERIMENTAL CRITICAL SKELETAL MUSCLE ISCHEMIA WITH A COMBINATION OF SIMVASTATIN AND UDENAFIL 2020
  • Fejziev Elvin Ejnulla Ogly
  • Belous Aleksandr Sergeevich
  • Sukovatykh Boris Semenovich
  • Trubnikova Elena Vladimirovna
RU2727891C1
METHOD FOR SKELETAL MUSCLE EXPERIMENTAL ISCHEMIA PHARMACOLOGICAL CORRECTION USING VARDENAFIL AND PENTOXIFYLLINE IN COMBINED THERAPY 2016
  • Lavrinenko Kristina Ivanovna
  • Belous Aleksandr Sergeevich
  • Mal Galina Sergeevna
  • Artyushkova Elena Borisovna
  • Polyakova Olga Vitalevna
  • Orlova Anzhelika Yurevna
  • Trubnikova Elena Vladimirovna
RU2618622C1
METHOD FOR SKELETAL MUSCLE EXPERIMENTAL ISCHEMIA PHARMACOLOGICAL CORRECTION USING TADALAFIL AND PENTOXIFYLLINE IN COMBINED THERAPY 2016
  • Lavrinenko Kristina Ivanovna
  • Belous Aleksandr Sergeevich
  • Mal Galina Sergeevna
  • Artyushkova Elena Borisovna
  • Polyakova Olga Vitalevna
  • Orlova Anzhelika Yurevna
  • Trubnikova Elena Vladimirovna
RU2618620C1
METHOD FOR PHARMACOLOGICAL CORRECTION OF EXPERIMENTAL CRITICAL SKELETAL MUSCLE ISCHEMIA WITH A COMBINATION OF SIMVASTATIN, UDENAFIL AND MONONUCLEAR FRACTION OF AUTOLOGOUS BONE MARROW 2020
  • Fejziev Elvin Ejnulla Ogly
  • Belous Aleksandr Sergeevich
  • Sukovatykh Boris Semenovich
  • Trubnikova Elena Vladimirovna
RU2726077C1
METHOD OF TADALAFIL-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY 2008
  • Pokrovskij Mikhail Vladimirovich
  • Chuljukova Tat'Jana Nikolaevna
  • Pokrovskaja Tat'Jana Grigor'Evna
  • Kochkarov Vladimir Iskhakovich
  • Gladchenko Mikhail Petrovich
  • Artjushkova Elena Borisovna
  • Novikov Oleg Olegovich
  • Novikova Marina Jur'Evna
  • Prusachenko Vladimir Konstantinovich
  • Grimova Taisija Aleksandrovna
  • Denisjuk Tat'Jana Alekseevna
  • Lazarenko Galina Stepanovna
  • Gureev Vladimir Vladimirovich
  • Tsepelev Vasilij Jur'Evich
  • Belous Aleksandr Sergeevich
  • Korokin Mikhail Viktorovich
  • Gudyrev Oleg Sergeevich
  • Tsybul'Skij Igor' Valer'Evich
  • Luchkina Elena Vadimovna
  • Ershov Il'Ja Nikolaevich
  • Khardikova Elena Mikhajlovna
RU2364395C1
METHOD FOR PHARMACOLOGICAL CORRECTION OF SCELETAL MUSCLE ISCHEMIA WITH MINOXIDIL 2012
  • Pokrovskij Mikhail Vladimirovich
  • Lazarenko Viktor Anatol'Evich
  • Kolesnik Inga Mikhajlovna
  • Efremenkova Dar'Ja Afonas'Evna
  • Pokrovskaja Tat'Jana Grigor'Evna
  • Dolzhikov Aleksandr Anatol'Evich
  • Khodov Sergej Vladimirovich
  • Gudyrev Oleg Sergeevich
  • Molchanova Ol'Ga Viktorovna
  • Kochkarov Vladimir Iskhakovich
  • Zhernakova Nina Ivanovna
  • Dolzhikova Irina Nikolaevna
  • Danilenko Ljudmila Mikhajlovna
  • Arustamova Anna Aleksandrovna
  • Gureev Vladimir Vladimirovich
  • Alekhin Sergej Aleksandrovich
  • Denisjuk Tat'Jana Alekseevna
  • Jakushev Vladimir Vladimirovich
RU2497200C1
METHOD FOR PHARMACOLOGICAL CORRECTION OF SKELETAL MUSCLE ISCHEMIA WITH NICORANDYL 2012
  • Pokrovskij Mikhail Vladimirovich
  • Lazarenko Viktor Anatol'Evich
  • Kolesnik Inga Mikhajlovna
  • Efremenkova Dar'Ja Afonas'Evna
  • Pokrovskaja Tat'Jana Grigor'Evna
  • Dolzhikov Aleksandr Anatol'Evich
  • Khodov Sergej Vladimirovich
  • Gudyrev Oleg Sergeevich
  • Molchanova Ol'Ga Viktorovna
  • Kochkarov Vladimir Iskhakovich
  • Zhernakova Nina Ivanovna
  • Dolzhikova Irina Nikolaevna
  • Danilenko Ljudmila Mikhajlovna
  • Papunashvili Mikhail Merabovich
  • Gureev Vladimir Vladimirovich
  • Alekhin Sergej Aleksandrovich
  • Trofimov Konstantin Sergeevich
  • Jakushev Vladimir Vladimirovich
RU2507597C2
METHOD FOR STIMULATING NEOANGIOGENESIS IN ISCHEMIC SKELETAL MUSCLE 2014
  • Kolesnik Inga Mikhajlovna
  • Pokrovskij Mikhail Vladimirovich
  • Lazarenko Viktor Anatol'Evich
RU2547692C1

RU 2 497 203 C2

Authors

Pokrovskij Mikhail Vladimirovich

Kolesnik Inga Mikhajlovna

Khodov Sergej Vladimirovich

Pokrovskaja Tat'Jana Grigor'Evna

Dolzhikov Aleksandr Anatol'Evich

Efremenkova Dar'Ja Afonas'Evna

Gudyrev Oleg Sergeevich

Molchanova Ol'Ga Viktorovna

Kochkarov Vladimir Iskhakovich

Zhernakova Nina Ivanovna

Dolzhikova Irina Nikolaevna

Danilenko Ljudmila Mikhajlovna

Bratchikov Oleg Ivanovich

Filimonov Vjacheslav Aleksandrovich

Arustamova Anna Aleksandrovna

Korokin Mikhail Viktorovich

Gureev Vladimir Vladimirovich

Korokina Lilija Viktorovna

Alekhin Sergej Aleksandrovich

Denisjuk Tat'Jana Alekseevna

Dates

2013-10-27Published

2012-02-13Filed