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2 497 203

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IPC

G09B23/28(2006-01-01)

A61K31/522(2006-01-01)

A61P9/10(2006-01-01)

(21) (22)

Application

2012104984/14, 2012-02-13

(24)

Start date

2012-02-13

(22)

Actual filing date

2012-02-13

(45)

Published

2013-10-27

(72)

Inventor

Pokrovskij Mikhail VladimirovichKolesnik Inga MikhajlovnaKhodov Sergej VladimirovichPokrovskaja Tat'Jana Grigor'EvnaDolzhikov Aleksandr Anatol'EvichEfremenkova Dar'Ja Afonas'EvnaGudyrev Oleg SergeevichMolchanova Ol'Ga ViktorovnaKochkarov Vladimir IskhakovichZhernakova Nina IvanovnaDolzhikova Irina NikolaevnaDanilenko Ljudmila MikhajlovnaBratchikov Oleg IvanovichFilimonov Vjacheslav AleksandrovichArustamova Anna AleksandrovnaKorokin Mikhail ViktorovichGureev Vladimir VladimirovichKorokina Lilija ViktorovnaAlekhin Sergej AleksandrovichDenisjuk Tat'Jana Alekseevna

(73)

Holder

Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Meditsinskij Universitet" Ministerstva Zdravookhranenija I Sotsial'Nogo Razvitija Rossijskoj Federatsii

METHOD OF PHARMACOLOGICAL CORRECTION OF SCELETAL MUSCLE ISCHEMIA WITH SILNEDAFIL INCLUDING IN L-NAME INDUCED NITROGEN OXIDE DEFICIENCY Russian patent published in 2013 - IPC G09B23/28 A61K31/522 A61P9/10 

Abstract RU 2497203 C2

FIELD: medicine.

SUBSTANCE: calf muscle ischemia is simulated, including in a combination with additional simulation of nitrogen oxide deficiency by intraperitoneal introduction of the nitrogen oxide synthesis blocker N-nitro-L-arginine of methyl ester (L-NAME) 25 mg/kg daily for 7 days. In both cases, the ischemia is corrected by intragastric introduction of sildenafil 2.2 mg/kg on the first, third and fifth days of experiment.

EFFECT: significant improvement of microcirculation in the ischemic calf muscle of rats.

1 tbl, 1 ex

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RU 2 497 203 C2

Authors

Pokrovskij Mikhail Vladimirovich

Kolesnik Inga Mikhajlovna

Khodov Sergej Vladimirovich

Pokrovskaja Tat'Jana Grigor'Evna

Dolzhikov Aleksandr Anatol'Evich

Efremenkova Dar'Ja Afonas'Evna

Gudyrev Oleg Sergeevich

Molchanova Ol'Ga Viktorovna

Kochkarov Vladimir Iskhakovich

Zhernakova Nina Ivanovna

Dolzhikova Irina Nikolaevna

Danilenko Ljudmila Mikhajlovna

Bratchikov Oleg Ivanovich

Filimonov Vjacheslav Aleksandrovich

Arustamova Anna Aleksandrovna

Korokin Mikhail Viktorovich

Gureev Vladimir Vladimirovich

Korokina Lilija Viktorovna

Alekhin Sergej Aleksandrovich

Denisjuk Tat'Jana Alekseevna

Dates

2013-10-27—Published

2012-02-13—Filed

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