FIELD: antibiotics and immunostimulating agents.
SUBSTANCE: disclosed is a CMAP27 derivative truncated from the N-terminus, wherein said derivative is selected from a group consisting of CMAP4-21, CMAP5-21, CMAP6-21, CMAP7-21, CMAP8-21, CMAP9-21, CMAP10-21, CMAP11-21, CMAP4-21 (F5→W), CMAP4-21 (F5→Y), CMAP4-21 (F12→W), CMAP4-21 (F12→Y), CMAP4-21 (F5, F12→W), CMAP4-21 (F5, F12→Y), CMAP4-21 (F5→W, F12→Y), CMAP4-21 (F5→Y, F12→W), CMAP7-21 (F12→W), CMAP7-21 (F12→Y), CMAP10-21 (F12→W) and CMAP10-21 (F12→Y). Also disclosed is a method for in ovo vaccination of poultry, a method of activating an immune response of an animal or human, an immunological composition, use of the CMAP27 derivative for preparing a medicinal agent for treating an infectious disease and preparing a vaccine, a method for increasing the weight of poultry by in ovo vaccination.
EFFECT: group of inventions provides effective antimicrobial activity.
11 cl, 13 dwg, 1 tbl, 7 ex
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