GROWTH HORMONE RECEPTOR BLOCKERS FOR DISEASE PREVENTION AND TREATMENT Russian patent published in 2020 - IPC C07D405/12 C07D405/14 G01N33/68 C07K14/72 A61K31/55 A61K31/4245 A61K31/4184 A61K39/395 A61P25/00 A61P25/28 A61P35/00 

Abstract RU 2726254 C2

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a method of inhibiting GH, GHR, STAT5, SOCS and c-fos, which involves identification of a subject having a disease or condition with changes in expression/activity of genes/proteins related to GH, human GHR, STAT5 and SOCS, or on which changes in expression/activity of genes/proteins related to human GH, GHR, STAT5 and SOCS, can have a beneficial effect; and administering a therapeutically effective amount of a compound selected from the group consisting of:

and their pharmaceutically acceptable salts.

EFFECT: technical result is novel activity of existing compounds and a method of inhibiting thereof, which can be used in medicine for treating cancer, diabetes, immunosuppression, Alzheimer's diseases and diseases and conditions, in respect of which cell and tissue regeneration has a favorable effect.

17 cl, 23 dwg

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RU 2 726 254 C2

Authors

Longo Valter D.

Balasubramanian Priya

Neamati Nouri

Wei Min

Dates

2020-07-10Published

2016-02-12Filed