CHIMERIC CYTOKINE RECEPTOR Russian patent published in 2024 - IPC C07K14/705 C07K16/32 C07K19/00 C12N5/783 C12N5/10 C12N15/09 A61K35/17 A61P35/00 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, specifically to chimeric cytokine receptors (CCR), and can be used in medicine for treating cancer. Disclosed is a nucleic acid construct for producing a cell which expresses a chimeric transmembrane protein, wherein said nucleic acid construct encodes a chimeric transmembrane protein and comprises a first nucleic acid sequence encoding a first polypeptide comprising a heavy chain (CH) constant domain dimerization domain and a first endodomain chain of a type I cytokine receptor; and a second nucleic acid sequence coding a second polypeptide comprising a light chain constant domain (CL) dimerisation domain which spontaneously heterodimerizes with said heavy chain constant domain (CH) dimerisation domain, and a second chain of endodomain of the type I cytokine receptor.

EFFECT: said chimeric transmembrane protein provides a constitutively active cytokine signal in said cell.

17 cl, 9 dwg, 1 tbl, 4 ex