FIELD: chemical or physical processes.
SUBSTANCE: invention relates to novel methods of producing dimeric indolinobenzodiazepine compounds and synthetic precursors thereof, which exclude the stage of partial reduction of indolinobenzodiazepine dimers containing two imine functional groups.
EFFECT: methods of the present invention provide desired dimer compounds with higher output without the need for cumbersome purification steps and are suitable for a large-scale production process.
81 cl, 20 ex, 13 dwg
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