FIELD: pharmacy.
SUBSTANCE: method comprises interaction (A) of at least one organomagnesium complex with (B) at least one coordinating compound in combination with zinc ions and lithium ions and halide ions, at that, the said halide ions are selected from chloride, bromide and iodide. The said coordinating compound is represented by the formula (I): R1Tq, where each T is -CO2- or -O-, R1 represents an alkyl group containing from 4 to 8 carbon atoms, and "q" is a positive integer. Options of organozinc reagents preparation and coordinating zinc complex are also proposed.
EFFECT: these reagents can be used for preparation of organic compounds by cross-coupling Negishi reactions, or by reaction of oxidative aldehyde or ketone addition.
15 cl, 1 dwg, 3 tbl, 8 ex
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Authors
Dates
2017-05-25—Published
2011-12-21—Filed