FIELD: chemistry.
SUBSTANCE: invention relates to new methods for the preparation of dimeric indolinobenzodiazepine compounds, for example, of the formula 18A and IA and their synthetic precursors.
EFFECT: new and improved processes for the preparation of indolinobenzodiazepine dimers that are more efficient and suitable for large scale manufacturing processes.
29 cl, 24 ex, 19 dwg
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