FIELD: biotechnology.
SUBSTANCE: invention relates to fused proteins, and can be used in medicine for inhibiting tumor growth. A fused protein comprising an immunoglobulin Fc region is obtained; and a version of ligand-3 of type CC (CCL3) having sequence SEQIDNO: 3, in which A or AP N-terminus are deleted and aspartic acid in amino acid position 27 from the N-terminus of CCL3 is replaced with alanine. In the obtained fused protein construct, the CCL3 variant is linked to the Fc immunoglobulin region through a linker, containing sequence SEQIDNO: 5, in order from N-terminus to C-terminal: version of CCL3, linker, immunoglobulin Fc region.
EFFECT: invention enables to obtain a fused protein having binding activity CCL3.
9 cl, 5 tbl, 4 ex, 6 dwg
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