FIELD: biotechnology.
SUBSTANCE: anticancer fusion protein and a pharmaceutical composition comprising it are disclosed. Anticancer fusion protein contains a first monomer comprising a variant of IL-12, and a second monomer comprising an antigen-binding site which specifically binds to FAP. Also disclosed are polynucleotides coding the fused protein, vectors and transformed cells for producing the fused protein.
EFFECT: fused protein according to the invention has high anticancer activity and can be used for anticancer therapy.
28 cl, 34 dwg, 12 tbl, 6 ex
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