APILIMOD FOR USE IN TREATING RENAL CANCER Russian patent published in 2020 - IPC A61K31/5377 A61P35/00 

FIELD: pharmaceutical industry.

SUBSTANCE: invention relates to use of a composition for treating renal cancer in a subject, as well as a method of treating renal cancer in a subject in need thereof, method of inhibiting the proliferation of renal cancer cells and a method of inhibiting the survival of renal cancer cells with a composition. Use of the composition containing a therapeutically effective amount of apilimod or its pharmaceutically acceptable salt for treating renal cancer in a subject. Method of treating renal cancer in a subject in need thereof, wherein said method comprises administering to a subject a therapeutically effective amount of a composition comprising apilimod or a pharmaceutically acceptable salt thereof. A method of inhibiting proliferation of renal cancer cells, wherein said method involves contacting cancer cells with such an amount of apilimod or a pharmaceutically acceptable salt thereof, which effectively inhibits cell proliferation. Kidney cancer cell survival inhibition method, wherein said method involves contacting cancer cells with such amount of apilimod or a pharmaceutically acceptable salt thereof, which effectively inhibits PIKfyve kinase activity in cancer cells.

EFFECT: composition described above and methods (versions) provide effective treatment of renal cancer in a subject.

31 cl, 21 dwg, 6 tbl, 5 ex