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2 729 187

(13)

(51)

IPC

C07D471/04(2006-01-01)

C07D487/04(2006-01-01)

A61K31/519(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2018115695, 2016-09-12

(24)

Start date

2016-09-12

(22)

Actual filing date

2016-09-12

(45)

Published

2020-08-05

(72)

Inventor

Matsuo, YoHisada, ShojiNakamura, YusukeChakrabarti, AnjanRawat, ManishRai, SanjaySatyanarayana, Arvapalli, VenkataDuan, ZhiyongTalukdar, ArindamRavula, SrinivasDecornez, Helene

(73)

Holder

Oncotherapy Science, Inc.

BICYCLIC COMPOUND AND USE THEREOF FOR SUV39H2 INHIBITION Russian patent published in 2020 - IPC C07D471/04 C07D487/04 A61K31/519 A61P35/00

Abstract RU 2729187 C1

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof:

Value of radicals R¹, R², R³, R⁵, R⁷, R⁸, X¹, X² and n is defined in the claim. What is also presented is a pharmaceutical composition, a method of treating or preventing a disease involving overexpression of SUV39H2, and use of the compound of formula (I) for preparing the drug.

EFFECT: disclosed compound has inhibitory activity on SUV39H2 and can be used for treating a malignant tumor.

18 cl, 13 tbl

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RU 2 729 187 C1

Authors

Matsuo, Yo

Hisada, Shoji

Nakamura, Yusuke

Chakrabarti, Anjan

Rawat, Manish

Rai, Sanjay

Satyanarayana, Arvapalli, Venkata

Duan, Zhiyong

Talukdar, Arindam

Ravula, Srinivas

Decornez, Helene

Dates

2020-08-05—Published

2016-09-12—Filed