IMIDAZOPYRIDIN-2-ONE DERIVATIVES, HAVING mTOR INHIBITING ACTIVITY Russian patent published in 2013 - IPC C07D471/04 C07D519/00 A61K31/437 A61K31/4709 A61K31/4725 A61P35/00 A61P35/02 

FIELD: chemistry.

SUBSTANCE: present invention relates to novel imidazopyridin-2-one derivatives of general formula or pharmacologically acceptable salts thereof, where (R¹)_n-A is a 1H-pyrrolo[2,3-b]pyridin-5-yl group, 3-chloro-1H-pyrrolo[2,3-b]pyridin-5-yl group, 4-chloro-1H-pyrrolo[2,3-b]pyridin-5-yl group, 3-fluoro-1H-pyrrolo[2,3-b]pyridin-5-yl group, 4-fluoro-1H-pyrrolo[2,3-b]pyridin-5-yl group, 3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl group, 4-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl group, 3,4-dimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl group, 3-fluoro-4-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl group or 3-chloro-4-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl group, B is a 3-6-member saturated or partially saturated monocyclic hydrocarbon group and can contain 1 or 2 oxygen atoms, a nitrogen atom and/or sulphonyl groups as ring components, B can have as substitutes identical or different R² in amount of m, R² is a substitute represented at a carbon atom or a nitrogen atom forming B, R² is a substitute selected from a group consisting of a hydroxy group, a halogen atom, a cyano group, an oxo group, a C_1-4alkyl group (where the C_1-4 alkyl group can be substituted with 1 C_1-4 alkoxy group) and a C_1-4 alkoxy group, when R² is a substitute represented at a carbon atom forming B, and R² is a substitute selected from a group consisting of a C_1-4 alkyl group and a C_1-4 alkylcarbonyl group, when R² is a substitute represented at a nitrogen atom forming B, m is any integer from 0 to 2, Q is a bond or a C_1-4 alkylene group, R³ and R⁴ are identical or different and each denotes a hydrogen atom or a halogen atom, and R⁵ and R⁶ are identical or different and each denotes a hydrogen atom, a halogen atom or a C_1-4 alkyl group. The invention also relates to specific compounds of formula (I), pharmacologically acceptable salts of compounds of formula (I), a pharmaceutical composition based on the compound of formula (I) and use of the compound of formula (I).

EFFECT: novel imidazopyridin-2-one derivatives, having mTOR inhibiting action, are obtained.

21 cl, 161 ex