FIELD: biochemistry.
SUBSTANCE: invention relates to an isolated antibody which specifically binds human TIGIT (hTIGIT), as well as to use thereof in treating a disease selected from cancer and viral infection. Also disclosed is an isolated polynucleotide encoding said antibody, a vector, a host cell containing it, as well as a method for producing an antibody, providing for antibody expression in said host cell. Invention also relates to a pharmaceutical composition for treating a disease which can be treated by an anti-TIGIT antibody containing an effective amount of said antibody, as well as to a method of treating or preventing a disease or pathology, in which treatment of an anti-TIGIT antibody involving the use of an anti-TIGIT antibody or a composition containing it can be useful.
EFFECT: invention enables effective treatment of a disease specified in cancer and viral infection.
87 cl, 14 dwg, 18 tbl, 11 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIGEN-BINDING PROTEINS AGAINST TIGIT AND THEIR APPLICATION METHODS | 2018 |
|
RU2776714C2 |
| BISPECIFIC CHECKPOINT INHIBITORS ANTIBODIES | 2017 |
|
RU2767357C2 |
| ANTI-TIGIT ANTIBODIES AND METHODS OF USING | 2016 |
|
RU2732591C2 |
| ANTI-TIGIT ANTIBODIES AND METHODS OF USE | 2016 |
|
RU2817838C2 |
| ANTIBODY TO TIGIT AND ITS USE | 2019 |
|
RU2786434C2 |
| ANTIBODIES AGAINST G-CSFR AND USE THEREOF | 2012 |
|
RU2605595C2 |
| MOLECULES WHICH BIND TO PSL PSEUDOMONAS, AND METHODS FOR USE THEREOF | 2012 |
|
RU2708977C2 |
| METHODS FOR DETECTING FOLATE RECEPTOR 1 IN PATIENT SAMPLE | 2018 |
|
RU2759410C2 |
| ANTIBODIES TO ICOS | 2016 |
|
RU2742241C2 |
| GLUCAGON RECEPTOR BINDING PROTEINS AND METHODS OF USE THEREOF | 2018 |
|
RU2820628C2 |
