FIELD: biochemistry.
SUBSTANCE: invention relates to biochemistry. Versions of antibody binding human granulocyte colony-stimulating factor receptor (hG-CSFR) are disclosed. Invention also discloses composition and method of treating G-CSF-mediated state in subject.
EFFECT: invention enables to bind hG-CSFR with high affinity and neutralize transmission of G-CSF signals.
13 cl, 4 dwg, 3 tbl, 6 ex
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