PHARMACEUTICAL AGENT AND METHOD FOR USE THEREOF FOR INDUCING SPECIFIC IMMUNITY TO VIRUS OF SEVERE ACUTE RESPIRATORY SYNDROME SARS-COV-2 (EMBODIMENTS) Russian patent published in 2020 - IPC A61K39/215 A61P31/14 C12N15/86 C12N7/00 

FIELD: biotechnology.

SUBSTANCE: invention refers to biotechnology, immunology and virology. There is created a pharmaceutical agent for inducing specific immunity to the virus of severe acute respiratory syndrome SARS-CoV-2, containing component 1 representing an agent in form of an expression vector based on the recombinant human adenovirus genotype of 26^th serotype in which the E1 and E3 regions are deleted, and the ORF6-Ad26 region is replaced by ORF6-Ad5, with an inbuilt expression cassette selected from SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, and containing component 2, which is an agent in the form of an expression vector based on the genome of recombinant human adenovirus strain of 5^th serotype in which E1 and E3 regions are deleted, with an inbuilt expression cassette selected from SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3. Also, a pharmaceutical agent for inducing specific immunity to the virus of severe acute respiratory syndrome SARS-CoV-2, containing component 1, which is an agent in form of an expression vector based on the genome of the recombinant human adenovirus strain of 26^th serotype, in which the E1 and E3 regions are deleted, and the ORF6-Ad26 region is replaced by ORF6-Ad5, with an inbuilt expression cassette selected from SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, as well as containing component 2, which is agent in form of expression vector based on recombinant strain of simian adenovirus 25^th serotype genome, in which the E1 and E3 regions are deleted, with an inbuilt expression cassette selected from SEQ ID NO: 4, SEQ ID NO: 2, SEQ ID NO: 3. There is also created a pharmaceutical agent for inducing specific immunity to the virus of severe acute respiratory syndrome SARS-CoV-2, containing component 1, representing an agent in the form of an expression vector based on the genome of the recombinant strain of simian adenovirus of 25^th serotype, in which the E1 and E3 regions are deleted, with an inbuilt expression cassette selected from SEQ ID NO: 4, SEQ ID NO: 2, SEQ ID NO: 3, as well as containing component 2, which is an agent in form of an expression vector based on genome of human recombinant strain of human adenovirus of 5^th serotype, in which E1 and E3 regions are deleted, with an inbuilt expression cassette selected from SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3. Each pharmaceutical agent is in a liquid or lyophilised form, and component 1 and component 2 are in different packages. Each pharmaceutical agent is used to induce specific immunity to the virus of severe acute respiratory syndrome SARS-CoV-2, wherein component 1 and 2 are used in an effective amount sequentially with an interval of not less than 1 week.

EFFECT: invention provides development of reactions of humoral and cellular immune response against SARS-CoV-2, thus providing increased level of immune response against virus SARS-CoV-2.

8 cl, 15 dwg, 4 tbl, 15 ex