IMMUNOBIOLOGICAL AGENT FOR INDUCING IMMUNE RESPONSE AGAINST LASSA VIRUS AND METHOD FOR USING IT Russian patent published in 2024 - IPC A61K39/12 C12N15/861 

Abstract RU 2823965 C1

FIELD: immunology; virology.

SUBSTANCE: there is created an immunobiological agent containing an expression vector based on the genome of a recombinant human adenovirus strain of 26th serotype, in which E1 and E3 regions are deleted, and the ORF6-Ad26 region is replaced by ORF6-Ad5, with an embedded SEQ ID NO: 1 expression cassette. In addition, there is created an immunobiological agent containing an expression vector based on the genome of the recombinant human adenovirus strain of 5th serotype, in which E1 and E3 regions are deleted, with an embedded SEQ ID NO: 1 expression cassette.

EFFECT: group of inventions provides effective induction of the immune response against Lassa virus and prevention of Lassa fever.

3 cl, 2 dwg, 8 tbl, 10 ex

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RU 2 823 965 C1

Authors

Popova Olga

Zubkova Olga Vadimovna

Ozharovskaia Tatiana Andreevna

Dolzhikova Inna Vadimovna

Grousova Daria Mikhailovna

Kovyrshina Anna Vitalevna

Zrelkin Denis Igorevich

Voronina Daria Vladimirovna

Shchebliakov Dmitrii Viktorovich

Esmagambetov Ilias Bulatovich

Dzharullaeva Alina Shakhmirovna

Tukhvatulin Amir Ildarovich

Tukhvatulina Natalia Mikhailovna

Shcherbinin Dmitrii Nikolaevich

Karpov Andrei Petrovich

Semikhin Aleksandr Sergeevich

Kovalchuk Aleksei Valerevich

Syromiatnikova Svetlana Ivanovna

Shatokhina Irina Viktorovna

Borisevich Sergei Vladimirovich

Naroditskii Boris Savelevich

Logunov Denis Iurevich

Gintsburg Aleksandr Leonidovich

Dates

2024-07-30Published

2024-02-05Filed