FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically to producing antibodies against the IgV domain of human TIM-3, and can be used in medicine for inhibiting human TIM-3, inhibiting TIM-3-mediated suppression of T cells in an individual, and treating TIM-3-positive malignant disease, as well as for detecting a human TIM-3-positive cell.
EFFECT: production of antibodies specifically binding to the IgV domain of human TIM-3 or IgV mucin-stem of human TIM-3 and containing a heavy chain with GYSFTGYTIN(CDR1), LFNPYNGGTT (CDR2), and ARRYYGYDAMDY (CDR3); as well as a light chain with KSSQSVLYSSNQKNHLA (CDR1); WASTRES (CDR2) and HQYLSSYT (CDR3).
22 cl, 6 dwg, 1 tbl, 1 ex
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