OXASPIRO DERIVATIVE, A METHOD FOR PRODUCTION THEREOF AND USE THEREOF IN MEDICINES Russian patent published in 2020 - IPC C07D405/04 C07D405/14 C07D409/14 A61K31/4402 A61K31/4433 A61K31/4436 

FIELD: organic chemistry.

SUBSTANCE: present invention relates to a compound of formula (I):

or a tautomer thereof, a mesomer, a racemate, an enantiomer, a diastereomer, or a mixture thereof, or a pharmaceutically acceptable salt thereof. To compound of formula (I) ring A is selected from a group consisting of C_3-6 cycloalkyl and 5–6-member heterocyclyl containing one nitrogen atom or one oxygen atom; R is selected from unsubstituted 5–6-member heteroaryl containing one nitrogen atom; each R¹ is identical to the other or different from it, and each is independently selected from a group consisting of a hydrogen atom and a halogen atom; each R² is identical or different from the other and each is independently selected from a group consisting of a hydrogen atom, C_1-6 alkyl, C_1-6 alkoxy, hydroxyl, oxo, =CH₂ and =CH-CN, where each of C_1-6 alkyl and C_1-6 alkoxy are optionally substituted with one or more groups selected from a group consisting of deuterium, C_1-6 alkyl, a halogen atom, cyano, C_1-6 alkoxy and C_3-6 cycloalkyl; or two R² together form unsubstituted 5–6 membered heterocyclyl containing two sulfur atoms or two oxygen atoms; p and q each independently represent 0, 1 or 2. Also disclosed is a method of producing a compound of formula (I), a pharmaceutical composition and use of compound (I).

EFFECT: technical result: disclosed is an oxaspiroderivative compound of general formula (I), which can be used as a MOR receptor agonist (μ-opioid receptor).

14 cl, 8 tbl, 31 ex