FIELD: pharmaceuticals.
SUBSTANCE: invention relates to a method of producing a compound of formula (II) or a pharmaceutically acceptable salt thereof, which comprises: a) reacting a compound of formula (III) or a salt thereof with hydrogen in the presence of a catalyst based on palladium (0) and/or platinum (0) and in the presence of an acid to form a compound of formula (I) or a salt thereof, where the reaction is carried out in the presence of water or in the presence of a mixture of water and a water-miscible solvent; b) reacting the obtained compound of formula (I) or a salt thereof with an activated derivative or precursor of acrylic acid and, if necessary, treatment with a base to form a compound of formula (II) and c) optionally forming a pharmaceutically acceptable salt thereof. Invention also relates to a method of producing a compound of formula (I) or a salt thereof.
(I)
(III).
EFFECT: novel method of producing a compound of formula (II) with high output.
19 cl, 2 tbl, 22 ex
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