METHOD OF REDUCTION OF CARBONYL-CONTAINING ACRIDINE DERIVATIVE OR ITS PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALT Russian patent published in 1996 - IPC

Abstract RU 2069659 C1

FIELD: organic chemistry. SUBSTANCE: product: carbonyl-containing derivative of acridine of the general formula (I) where R - hydrogen atom, R′ - hydrogen atom or benzyl, or its pharmaceutically acceptable acid-additive salt is reduced in the presence of catalyst based on noble metal under hydrogen pressure. Process is carried out in medium of lower alkanol, at 50-100 C in the presence of lithium oxide hydrate and corresponding derivative of acridine-1-ol of the general formula (II) where R and have the same values or its pharmaceutically acceptable salt is obtained. ???EFFECT: improved method of synthesis.

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RU 2 069 659 C1

Authors

Tomas Bin Kin Li[Hk]

Dzhordzh Ehverett Li[Us]

Dzhordzh S.K.Vong[Hk]

Donna M.Borek[Us]

Kijt E.Gering[Us]

Dates

1996-11-27Published

1991-03-28Filed